Publications

Demetriou AA, Whiting J, Levenson AM, Chowdhury NR, Schechner R, Michalski S, Feldman D, Chowdhury JR. New method of hepatocyte transplantation and extracorporeal liver support. Ann Surg 204: 259-271 (1986).

Arnaout WS, Moscioni AD, Barbour RL, Demetriou AA. Development of a bioartificial liver: bilirubin conjugation in Gunn rats. J Surg Res 48: 379-382 (1990).

Neuzil DF, Rozga J, Moscioni AD, Ro MS, Moscioni AD, Hakim R, Arnout WS, Demetriou AA. Use of a novel bioartificial liver in a patient with acute liver insufficiency. Surgery, 113: 340-343 (1993).

Georgio T, Moscioni AD, Rozga J, Demetriou AA. Mass Transfer in a Hollow Fiber Device Used as a Bioartificial Liver. Transactions ASAIO, 39: 886-892 (1993).

Rozga J, Holzman MD, Ro MS, Griffin DW, Neuzil DF, Giorgio T, Moscioni AD, Demetriou AA. Hybrid Bioartificial Liver Support Treatment of Animals with Severe Ischemic Liver Failure. Ann. Surg., 217: 502-511 (1993).

Rozga J, Williams RF, Moscioni AD, Giorgio T, Ro MS, Daniel Neuzil, Hakim R, Demetriou AA. Development of a bioartificial liver support system. Hepatology, 17: 258-264 (1993).

Rozga J, Podesta L, LePage E, Hoffman A, Morsiani E, Sher L, Woolf GM, Makowka L, Demetriou AA. Control of cerebral oedema by total hepatectomy and extracorporeal liver support in fulminant hepatic failure. Lancet, 342: 898-899 (1993).

Ash SR, Carr DJ, Blake DE, Rainier JB, Demetriou AA, Rozga J. Effect of sorbent-based dialytic therapy with the Biologic-DT on an experimental model of hepatic failure. ASAIO Journal 39, M675-M680 (1993).

Rozga J, Moscioni D, Morsiani E, Demetriou AA. Isolated Hepatocytes in a Bioartificial Liver: A Single Group View and Experience. Biotechnology & Bioengineering, 54: 645-653 (1994).

Rozga J, LePage EB, Moscioni AD, Podesta L, Villamil F, Hoffman A, Rosenthal P, Morsiani E, Makowka L, Demetriou AA. A Bioartificial Liver to Treat Severe Acute Liver Failure. Annals of Surgery, 219: 538-546 (1994).

LePage EB, Rozga J, Rosenthal P, Watanabe F, Scott HC, Talke AM, Demetriou AA. A Bioartificial Liver Used As A Bridge To Liver Transplantation in a 10 Year Old Boy. Am. J. Crit. Care Med., 3: 224-227 (1994).

Demetriou AA., Rozga J, Podesta L, LePage E, Morsiani E, Moscioni D, Hoffman A, McGrath M, Kong L, Rosen H, Villamil F, Woolf G,m Vierling J, Makowka L. Early Clinical Experience with a Hybrid Bioartificial Liver. Bioartificial Liver. Scand. J. Gastroenterol. 203 (30 suppl.), 111-117 (1995).

Morsiani E, Rozga J, Scott H.C., Kong L.B., Lebow L.T., McGrath M.F., Moscioni A.D., Demetriou A.A. Automated Large-Scale Production of Porcine Hepatocytes for Bioartificial Liver Support. Transplant. Proc. 26 (6): 4105-4106 (1994).

Morsiani E, Rozga J, Scott H, Lebow L, Moscioni AD, Kong L, McGrath M, Rosen H, Demetriou AA. Automated Liver Cell Processing Facilitates Large-Scale Isolation and Purification of Porcine Hepatocytes. ASAIO Journal 41:155-161 (1995).

LePage EB, Lane R, McKay D, Rozga J, Demetriou AA. Plasma Separation For Artificial Liver Support. J. Clin. Apheresis 10: 70-75 (1995).

Kamlot A, Rozga J, Watanabe FD, Demetriou AA. Review: Artificial Liver Support Systems. Ð Biotechnol. Bioeng. 50: 382-391 (1996).

Kong LB, Chen S, Demetriou AA, Rozga J. Matrix-induced liver cell aggregates (MILCA) for bioartificial liver use. - Int. J. Artif. Organs 19: 43-49 (1996).

Rozga J, Demetriou AA. Artificial Liver: Evolution and Future Perspectives. - ASAIO Journal 41: 831-837 (1996).

Chen S, Eguchi S, Watanabe F, Hewitt W, Kahaku E, Middleton Y, Arnaout W, Rozga J, Demetriou AA. Hepatic support strategies. Ð Transplant. Proc. 28:2036-2038 (1996).

Pazzi P, Morsiani E, Moscioni AD, Rozga J, Gullini S, Demetriou AA. Cholate handling by a bioartificial liver. It. J. Gastroenterol. 27 (suppl.1): 191-192 (1996).

Chen SC, Hewitt WR, Eguchi S, Watanabe F, Arkadopoulos N, Corno V, Suh KS, Middleton Y, Rodriguez O, Kahaku E, Lane RA, Demetriou AA, Rozga J. Prolonged survival in anhepatic pigs treated with a bioartificial liver. Surg. Forum 47: 161-163 (1996).

Eguchi S, Kamlot A, Ljubimova J, Hewitt W, Demetriou AA, Rozga J. Fulminant Hepatic Failure in Rats: Survival and Effects on Blood Chemistry and Liver Regeneration. Hepatology 24: 1452-1459 (1996).

Chen SC, Hewitt WR, Rozga J, Watanabe F, Eguchi S, Kahaku E, Middleton Y, Demetriou AA. Clinical experience with a porcine hepatocyte-based liver support system. Int. J. Artif. Organs 19 (11): 664-669 (1996).

Hewitt WR, Corno V, Eguchi S, Kamlot A, Middleton Y, Beeker T, Demetriou AA, Rozga J. Isolation of Human Hepatocytes from Livers Rejected From Whole Organ Transplantation. Transplant. Proc. 29: 1945-7 (1997).

Watanabe F, Mullon C J-P, Hewitt WR, Arkadopoulos N, Kahaku E, Eguchi S, Khalili T, Arnaout W, Shackleton CR, Rozga J, Solomon B, Demetriou AA. Clinical Experience with a Bioartificial Liver (BAL) in the Treatment of Severe Liver Failure: A Phase I Clinical Trial. Ann. Surg. 5: 484-494 (1997).

Chen SC, Mullon C J-P, Kahaku E, Watanabe F, Hewitt W, Eguchi S, Middleton Y, Arkadopoulos N, Rozga J, Solomon B, Demetriou AA. Treatment of severe liver failure with a bioartificial liver. Ann NY Acad Sci 831: 350-360 (1997).

Demetriou AA. Support of trhe acutely failing liver: State of the Art. Ann Surg 228: 14-15 (1998).

Morsiani E, Pazzi P, Moscioni AD, Rozga J, Azzena G, Demetriou AA. In vitro Morphological and Functional Characterization of Isolated Porcine Hepatocytes for Extracorporeal Liver Support: Bile Acid Uptake and Conjugation. J Surg Res 79: 54-60 (1998).

Arkadopoulos N, Detry O, Rozga J, Demetriou AA. Liver asssist systems: State of the Art. Int J Artif Organs 21: 119-125 (1998).

Kamohara Y, Rozga J, Demetriou AA. Artificial Liver: Review and Cedars-Sinai experience. J. Hepatobiliary Pancreat. Surg. 5: 273-285 (1998).

Rozga J, Demetriou AA. Clinical experience with a bioartificial liver.Med. Sc. Monitor 5(suppl.1): 165-171 (1999).

Arnaout W, Watanabe FD, Kahaku E, Navarro A, Ting P, Rozga J, Demetriou AA. Bioartificial liver support system for severe acute liver failure: summary of clinical experience. Organs Tissue 2:95-101 (1999).

Detry O, Ting P, Arkadopoulos N, Kahaku E, Watanabe F, Rozga J, Demetriou AA. Clinical use of a bioartificial liver in the treatment of acetaminophen-induced fulminant hepatic failure. Am. Surg. 65: 934-938 (1999).

Pitkin Z, Mullon C. Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with a bioartificial liver support system. Artif Organs 23: 829-833 (1999).

Ting P, Suh K-S, Navarro A, Demetriou AA, Rozga J.Bioartificial liver lowers blood interleukin-10 and transforming growth factor b1. Surg. Forum 50, 7-8 (1999).

Suk KS, Lilja H, Kamohara Y, Eguchi S, Arkadopoulos N, Neuman T, Demetriou AA, Rozga J. Bioartificial liver treatment in fulminant hepatic failure rats: effect on DNA binding activity of growth-induced and liver-enriched transcription factors. J. Surg. Res. 85: 243-250 (1999).

Ting P, Rozga J, Demetriou AA. Clinical Experience with Artificial Liver Support Systems. Can J Gastroenterol 14 Suppl. D: 79D - 84D (2000).

Hui T, Rozga J, Demetriou AA. Bioartificial liver support. J Hepatobiliary Pancreat Surg 2001; 8: 1-15.

Rozga J. Extracorporeal support of the failing liver. Med Sci Monitor 7(Suppl 1): 78-90 (2001).

Khalili TM, Navarro A, Ting P, Kamohara Y, Arkadopoulos N, Solomon B, Demetriou AA, Rozga J. Bioartificial liver treatment prolongs survival and lowers intracranial pressure in pigs with fulminant hepatic failure. Artif Organs 25: 566-570 (2001).

Sugiyama N, Rozga J, Demetriou AA. Biological Extracorporeal Liver Assist Devices: A Mini-Review. Transplant Reviews 2001.

Pazzi P, Morsiani E, Vilei MT, Granato A, Rozga J, Demetriou AA, Muraca M. Serum bile acids in patients with liver failure supported with a bioartificial liver. Aliment Pharmacol Ther 16: 1547-1554 (2002).

Demetriou AA, Brown RS, Busuttil RW, Fair J, McGuire BM, Rosenthal P, Esch JMA, II, Lerut J, Nyberg SL, Salizzoni M, Fagan EA, de Hemptinne B, Broelsch CE, Muraca M, Salmeron JM, Rabkin JM, Metselaar HJ, Pratt D, De La Mata M, McChesney LP, Everson GT, Lavin PT, Stevens AC, Pitkin Z, Solomon BA. Prospective, Randomized, Multicenter, Controlled Trial of a Bioartificial Liver in Treating Acute Liver Failure. Ann Surg 239: 660-670 (2004).

Demetriou, A. et al. “Prospective, Randomized, Multicenter, Controlled Trial of a Bioartificial Liver in Treating Acute Liver Failure.” Annals of Surgery, Volume 239, Number 5, May 2004.
 
Rozga, J. “Artificial Support of the Failing Liver.” U.S. Gastroenterology Review, 2006.
 
Rozga, J., Umehara, Y., Trofimenko, A., Sadahiro, T., Demetriou, A. “A Novel Plasma Filtration Therapy for Hepatic Failure: Preclinical Studies.” Therapeutic Apheresis and Dialysis, Blackwell Publishing Pty Ltd.; Volume 10, No. 2: 138-144, 2006.

Chapters (Books and Textbooks)

Rozga J, Podesta L, Hoffman A, LePage E, Morsiani E, Moscioni AD, Demetriou AA. Development and Testing of a Bioartificial Liver. In: Internatinal Developments In Surgery And Surgical Research. Braverman MH and Tawes RL (eds.). Surgical Technology International II, San Francisco, CA, pp.215-218 (1993).

Support of the Acutely Failing Liver. Demetriou AA (ed). R.G. Landes Co., Biomedical Publishers Medical Intelligence Unit, TX, USA, 1994.

Demetriou AA, Watanabe F, Rozga J. Artificial Hepatic Support Systems. In: Progress in Liver Diseases. JL Boyer, RK Ockner (eds.). W.B.Saunders Co., Philadelphia, vol.XIII., pp. 331-348, 1995.

Rozga J, Demetriou AA. Artificial Liver Support. In: Liver Growth and Repair: From Basic Science to Clinical Practice (eds. A. Strain and A-M.Diehl). Chapman and Hall Ltd, 1997.

Eguchi S, Chen SC, Rozga J, Demetriou AA. Tissue engineering: Liver. In: Yearbook of Cell and Tissue Transplantation. R.P.Lanza adn W.L.Chick (eds.), Kluwer Academic Publishers, Netherlands , pp.247-252, 1996/97.

Rozga J, Lilja H, Suk Suh K, Eguchi S, Neuman T, Demetriou AA. A bioartificial liver: how does it work ? In: "Bioartificial liver support systems - the critical issues." Eds.G.Crepaldi, A.A.Demetriou and M.Muraca. International Up To Date - 208, CIC Edizioni Internazionali, Via Lazzaro Spallanzani, 11-00161 Rome, Italy, pp.98-103 (1997).

Pazzi P, Morsiani E, Muraca M, Vilei MT, Rozga J, Demetriou AA. Metabolic characterization of bioartificial liver: focus on bile production and excretion. In: "Bioartificial liver support systems - the critical issues." Eds.G.Crepaldi, A.A.Demetriou and M.Muraca. International Up To Date - 208, CIC Edizioni Internazionali, Via Lazzaro Spallanzani, 11-00161 Rome, Italy, pp.90-97 (1997).

Chen SC, Mullon C, Kahaku E, Watanabe F, Hewitt W, Eguchi S, Middleton Y, Arkadopoulos N, Rozga J, Solomon B, Demetriou AA. Treatment of Severe Liver Failure with a Bioartificial Liver. In: Bioartificial Organs: Science, Medicine and Technology. A.Prokop, D.Hunkeler and A.D.Cherrington (eds), The New York Academy of Sciences, vol.831, pp. 350-360 (1997).

Hewitt WR, Rozga J, Mullon CJP, Demetriou AA. Bioartificial liver: experimental and clinical experience. In: Ilots de Langerhans et hepatocytes. Vers une utilisation therapeutique. D Franco, K Boudjema, B Varet (eds). Les Editions INSERM; pp:105-118 (1998).

Demetriou AA, Rozga J. Artificial Liver Support. In: Liver Growth and Repair. A Strain and AM Diehl (eds). Chapman & Hall, London, UK, 1998; pp.627-652.

Support of the Acutely Failing Liver (2nd edition). Demetriou AA (ed). R.G. Landes Co., Biomedical Publishers Medical Intelligence Unit, TX, USA, 2000.

Rozga J, Demetriou AA. Support of the failing liver. In: Surgery of the Liver and Biliary Tract, Blumgart LH and Fong Y (eds), III edition, 2000, W.B.Saunders, London, UK.

Rozga J, Demetriou AA. Animal Models of Liver Failure. In: Surgical Research. WW Souba & DW Wilmore (eds), Academic Press, San Diego, CA, 2001, pp.623.-636.

Rozga J, Demetriou AA. Development and testing of a bioartificial liver. In: The Hepatocyte Review and Research. MN Berry & AM Edwards (eds.), Kulwer Academic Publishers, Netherlands, 2001, pp.1-15.

Pitkin Z, Switzer W, Chapman L. An interim analysis of PERV infectivity in 74 patients treated with a bioartificial liver in a prospective, randomized, multicenter controlled trial. Hepatology 34:249A (2001).